Journal article

The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study

Jason A Roberts, Gavin M Joynt, Anna Lee, Gordon Choi, Rinaldo Bellomo, Salmaan Kanji, M Yugan Mudaliar, Sandra L Peake, Dianne Stephens, Fabio Silvio Taccone, Marta Ulldemolins, Miia Maaria Valkonen, Julius Agbeve, Joao P Baptista, Vasileios Bekos, Clement Boidin, Alexander Brinkmann, Luke Buizen, Pedro Castro, C Louise Cole Show all

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2021

Abstract

BACKGROUND: The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT techniques and antibiotic dosing in critically ill patients receiving RRT and relate observed trough antibiotic concentrations to optimal targets. METHODS: We performed a prospective, observational, multinational, pharmacokinetic study in 29 intensive care units from 14 countries. We collected demographic, clinical, and RRT data. We measured trough antibiotic concentrations of meropenem, piperacillin-tazobactam, and vancomycin and related them to high- and low-target trough concentrations. RESULTS: We studied 381..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Centre for Research Excellence


Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China



Funding Acknowledgements

This work was supported by funding from the National Health and Medical Research Council (project grant APP1044941), the Centre for Research Excellence (grant APP1099452), and a Practitioner Fellowship to J. A. R., (grant APP1117065). Partial support was provided by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (project number CUHK 14106614). Support was also provided by the Australian Government's National Collaborative Research Infrastructure Strategy (NCRIS) initiative through Therapeutic Innovation Australia (to S. K. P).