Journal article

Nerve guidance conduit design based on self-rolling tubes.

TB Aigner, C Haynl, S Salehi, A O'Connor, T Scheibel

Materials Today Bio | Elsevier | Published : 2020

Abstract

The current gold standard in peripheral nerve repair is nerve autografts for bridging gaps larger than a centimeter. However, autografts are associated with a low availability and the loss of function at the donor site. Nerve guidance conduits (NGCs) made of biocompatible and biodegradable materials reflect suitable alternatives. Clinically approved NGCs comprise either wraps that are rolled around the loose ends of the nerve or steady-state tubes; however, both lack internal guidance structures. Here, we established self-rolling NGCs to allow for gentle encapsulation of nerve cells together with supportive microenvironments, such as (1) an inner tube wall coating with a bioactive spider sil..

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University of Melbourne Researchers

Grants

Awarded by Bavarian Research Foundation


Awarded by Deutsche Forschungsgemeinschaft