Three-step two-pot automated production of NCA [F-18]FDOPA with FlexLab module
Ya-Yao Huang, Stan Poniger, Chia-Ling Tsai, Henri J Tochon-Danguy, Uwe Ackermann, Ruoh-Fang Yen
APPLIED RADIATION AND ISOTOPES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [18F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [18F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.
Awarded by Ministry of Science and Technology of Taiwan
Awarded by National Taiwan University Hospital
The authors thank the staffs of PET Radiochemistry Laboratory of NTUH for technical support. Mr. Chi-Han Wu is acknowledged for language corrections. This work was supported by the Ministry of Science and Technology of Taiwan (Grants MOST 105-2314-B-002-091) and National Taiwan University Hospital (Grant NTUH.104-N2869 and NTUH. 108-S4177).