New Approaches to SCLC Therapy: From the Laboratory to the Clinic
John T Poirier, Julie George, Taofeek K Owonikoko, Anton Berns, Elisabeth Brambilla, Lauren A Byers, David Carbone, Huanhuan J Chen, Camilla L Christensen, Caroline Dive, Anna Farago, Ramaswamy Govindan, Christine Hann, Matthew D Hellmann, Leora Horn, Jane E Johnson, Young S Ju, Sumin Kang, Mark Krasnow, James Lee Show all
Journal of Thoracic Oncology | ELSEVIER SCIENCE INC | Published : 2020
The outcomes of patients with SCLC have not yet been substantially impacted by the revolution in precision oncology, primarily owing to a paucity of genetic alterations in actionable driver oncogenes. Nevertheless, systemic therapies that include immunotherapy are beginning to show promise in the clinic. Although, these results are encouraging, many patients do not respond to, or rapidly recur after, current regimens, necessitating alternative or complementary therapeutic strategies. In this review, we discuss ongoing investigations into the pathobiology of this recalcitrant cancer and the therapeutic vulnerabilities that are exposed by the disease state. Included within this discussion, is ..View full abstract
Awarded by National Institutes of Health (NIH)
Awarded by NCI Small Cell Research Consortium Coordinating Center
The authors were supported by grants from the National Institutes of Health (NIH) R01 CA213448 (Dr. Poirier and Dr. Rudin), U01 CA213359 (Dr. Poirier), U01 CA231844 (Dr. Oliver and Dr. Govindan), U24 CA213274 (Dr. Rudin and Dr. Oliver), U01 CA213338 (Dr. Minna), R21 CA216504 (Dr. Oliver), and R01 CA207295 (Dr. Byers). The NCI Small Cell Research Consortium Coordinating Center (U24 CA213274) and the International Association for the Study of Lung Cancer supported the meeting on which this review is based. The authors also thank Dr. Peter Ujhazy, Dr. Eva Szabo, and Dr. Suzanne Forry from the National Cancer Institute (NCI), and Dr. Adi Gazdar, whose pioneering work has greatly impacted the discoveries described in this study, and to whom the Third Biennial International Association for the Study of Lung Cancer (IASLC) SCLC meeting and this manuscript was dedicated to.