Journal article

Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy

Ling Ling Chua, Reena Rajasuriar, Yvonne Ai Lian Lim, Yin Ling Woo, P'ng Loke, Hany Ariffin

BMC Cancer | BMC | Published : 2020

Abstract

BACKGROUND: Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer treatment has not been evaluated. This study examines the chronological changes of gut microbiota in children with acute lymphoblastic leukemia (ALL) prior to the start-, during-, and following cessation of chemotherapy. METHODOLOGY: We conducted a longitudinal observational study in gut microbiota profile in a group of paediatric patients diagnosed with ALL using 16 s ribosomal RNA sequencing and compared these patients' microbiota pattern with age and ethnicity-matched he..

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University of Melbourne Researchers

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Awarded by UMRG


Awarded by PPP grant


Awarded by NIH


Awarded by Department of Defense


Funding Acknowledgements

H.A. and L.L.C. were funded by UMRG grant RP049A-17HTM, W.Y.L. and L.L.C. were funded by PPP grant PG346-2016A and P.L. is supported by grants from the NIH (HL084312, AI133977, AI130945) and the Department of Defense (W81XWH-16-1-0255). The funding bodies had no role in the study design, collection, analysis and interpretation of data, in writing the manuscript, or in the decision to submit the paper for publication.