Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606
Yan Zhu, Jing Lu, Jinxin Zhao, Xinru Zhang, Heidi H Yu, Tony Velkov, Jian Li
International Journal of Medical Microbiology | ELSEVIER GMBH | Published : 2020
Multidrug-resistant (MDR) Acinetobacter baumannii is a critical threat to global health. The type strain ATCC 19606 has been widely used in studying the virulence, pathogenesis and mechanisms of antimicrobial resistance in A. baumannii. However, the lack of a complete genome sequence is a hindrance towards detailed bioinformatic studies. Here we report the generation of a complete genome for ATCC 19606 using PacBio sequencing. ATCC 19606 genome consists of a 3,980,848-bp chromosome and a 9,450-bp plasmid pMAC, and harbours a chromosomal dihydropteroate synthase gene sul2 conferring resistance to sulphonamides and a plasmid-borne ohr gene conferring resistance to peroxides. The genome also co..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health
J.L and T.V. are supported by the Australian National Health and Medical Research Council (NHMRC) project grant (APP1104581) and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI132154). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. T.V. is an Australian NHMRC Career Development Research Fellow and J.L. is an Australian NHMRC Principal Research Fellow.