Journal article

Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease

Kunal Dhiman, Veer Bala Gupta, Victor L Villemagne, Dhamidhu Eratne, Petra L Graham, Christopher Fowler, Pierrick Bourgeat, Qiao-Xin Li, Steven Collins, Ashley Bush, Christopher C Rowe, Colin L Masters, David Ames, Eugene Hone, Kaj Blennow, Henrik Zetterberg, Ralph N Martins



Introduction: This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology, as well as its potential to predict brain atrophy, cognition, and amyloid accumulation. Methods: CSF NfL concentration was measured in 221 participants from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL). Results: CSF NfL levels as well as NfL/amyloid β (Aβ42) were significantly elevated in AD compared to healthy controls (HC; P < .001), and in mild cognitive impairment (MCI) compared to HC (P = .008 NfL; P < .001 NfL/Aβ42). CSF NfL and NfL/Aβ42 differentiated AD from HC with..

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Awarded by NHMRC Practitioner Fellowship

Funding Acknowledgements

The authors thank the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL) Study Group (, Edith Cowan University (ECU) and Deakin University. The AIBL is a collaboration between the Commonwealth Scientific and Industrial Research Organisation (CSIRO), ECU, The Florey Institute of Neuroscience and Mental Health (FINMH), National Ageing Research Institute (NARI), and Austin Health. It involves support from CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The initial core funding of the study was facilitated by CSIRO. The study receives funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC2), the Cooperative Research Centre (CRC) for Mental Health, and the Australian Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria. The authors also thank the participants for their assistance and commitment. K.D. also thanks ECU HDR (Higher degree by research) Scholarship. K.B. is supported by the Torsten Soderberg foundation, Sweden. H.Z. is a Wallenberg Academy Fellow supported by grants from the Swedish Research Council, the European Research Council, the Olav Thon Foundation, and the UK Dementia Research Institute at UCL. S.C. receives a NHMRC Practitioner Fellowship (#APP1105784).