Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test
Habtamu B Beyene, Steven Hamley, Corey Giles, Kevin Huynh, Alexander Smith, Michelle Cinel, Natalie A Mellet, Maria G Morales-Scholz, Danielle Kloosterman, Kirsten F Howlett, Greg M Kowalski, Christopher S Shaw, Dianna J Magliano, Clinton R Bruce, Peter J Meikle
The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2020
CONTEXT: Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and better understand mechanisms of IR associated with abnormal lipid metabolism. OBJECTIVE: The objective of this article is to determine plasma lipid species associated with indices of IR and evaluate the lipidome response to an oral glucose tolerance test (OGTT). DESIGN AND SETTING: This study was community based and cross-sectional. PARTICIPANTS AND SAMPLE: Plasma samples (collected at 0 and 120 min during an OGTT) from nonobese, young adults age 18 to 34 years (n = 246) were analyzed using liquid chromatography-tandem mass spectrometry. MAIN OUTCOME MEASURES: The a..View full abstract
Awarded by Australian Research Council
This work was supported by Australian Research Council Fellowships (Grant DE180100859 to G.M.K.) and (Grant FT160100017 to C.R.B.) and a Monash Graduate Scholarship and a Monash International Postgraduate Research Scholarship from Monash University, Melbourne, Australia (to H.B.B.). We also acknowledge the Operational Infrastructure Support Scheme of the Victorian State Government, Victoria, Australia.