Journal article

Variability in echocardiography and MRI for detection of cancer therapy cardiotoxicity

James Lambert, Mariana Lamacie, Babitha Thampinathan, Mustafa A Altaha, Maryam Esmaeilzadeh, Mark Nolan, Camila Urzua Fresno, Emily Somerset, Eitan Amir, Thomas H Marwick, Bernd J Wintersperger, Paaladinesh Thavendiranathan

Heart | BMJ PUBLISHING GROUP | Published : 2020


OBJECTIVES: To compare variability of echocardiographic and cardiovascular magnetic resonance (CMR) measured left ventricular (LV) function parameters and their relationship to cancer therapeutics-related cardiac dysfunction (CTRCD). METHODS: We prospectively recruited 60 participants (age: 49.8±11.6 years), 30 women with human epidermal growth factor receptor 2-positive breast cancer (15 with CTRCD and 15 without CTRCD) and 30 healthy volunteers. Patients were treated with anthracyclines and trastuzumab. Participants underwent three serial CMR (1.5T) and echocardiography studies at ~3-month intervals. Cine-CMR for LV ejection fraction (LVEF), myocardial tagging for global longitudinal strai..

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