Variability in echocardiography and MRI for detection of cancer therapy cardiotoxicity
James Lambert, Mariana Lamacie, Babitha Thampinathan, Mustafa A Altaha, Maryam Esmaeilzadeh, Mark Nolan, Camila Urzua Fresno, Emily Somerset, Eitan Amir, Thomas H Marwick, Bernd J Wintersperger, Paaladinesh Thavendiranathan
HEART | BMJ PUBLISHING GROUP | Published : 2020
OBJECTIVES: To compare variability of echocardiographic and cardiovascular magnetic resonance (CMR) measured left ventricular (LV) function parameters and their relationship to cancer therapeutics-related cardiac dysfunction (CTRCD). METHODS: We prospectively recruited 60 participants (age: 49.8±11.6 years), 30 women with human epidermal growth factor receptor 2-positive breast cancer (15 with CTRCD and 15 without CTRCD) and 30 healthy volunteers. Patients were treated with anthracyclines and trastuzumab. Participants underwent three serial CMR (1.5T) and echocardiography studies at ~3-month intervals. Cine-CMR for LV ejection fraction (LVEF), myocardial tagging for global longitudinal strai..View full abstract
Awarded by Canadian Institutes of Health Research
This study was funded by an operating grant from the Canadian Institutes of Health Research (137132 and 142456). Dr Thavendiranathan (147814) is supported by the Canadian Institutes of Health Research New Investigator Award.