Journal article

Peptide Programmed Hydrogels as Safe Sanctuary Microenvironments for Cell Transplantation

Y Wang, X He, KF Bruggeman, B Gayen, A Tricoli, WM Lee, RJ Williams, DR Nisbet

Advanced Functional Materials | Wiley | Published : 2020

Abstract

Cell transplantation is one of the most promising strategies for the minimally invasive treatment of a raft of injuries and diseases. However, a standing challenge to its efficacy is poor cell survival due to a lack of mechanical protection during administration and an unsupportive milieu thereafter. In response, a shear-injectable nanoscaffold vector is engineered considering the three equal requirements of protection, support, and survival. Here, the programmed peptide assembly of tissue-specific epitopes presents a safe sanctuary microenvironment for the transplantation of cells. For the first time, a mechanistic understanding of the multifactorial role of the nanoscaffold in promoting ce..

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Grants

Awarded by Australian Research Council


Awarded by National Health and Medical Research Council


Funding Acknowledgements

D.N. and R.W. contributed equally to this work and Y.W. and X.H. are equal first author. This study was supported by funding from an ARC discovery project (DP130103131) and the NHMRC project (GNT1144996). Y.W. was supported by the Australian National University Student Ph.D. Scholarship (International) and X.F.H. was supported by a CSC-ANU PhD Scholarship; K.F.B. was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Scholarship Doctoral (PGS D) award; B.G. was supported by RJL Hawke Fellowship from Australian Antarctic Division; A.T. was supported by a ARC DECRA (DE160100569) and Westpac2016 Research Fellowship; W.M.L. was supported by an ARC DECRA (DE160100843); and D.R.N. was supported by a NHMRC Dementia Research Leadership Fellowship (GNT1135687). Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged.