Microelectrode array electrical impedance tomography for fast functional imaging in the thalamus
Danyi Zhu, Alistair McEwan, Calvin Eiber
NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019
Electrical Impedance Tomography (EIT) has the potential to be able to observe functional tomographic images of neural activity in the brain at millisecond time-scales. Prior modelling and experimental work has shown that EIT is capable of imaging impedance changes from neural depolarisation in rat somatosensory cortex. Here, we investigate the feasibility of EIT for imaging impedance changes using a stereotaxically implanted microelectrode array in the thalamus. Microelectrode array EIT was simulated using an anatomically accurate marmoset brain model. Impedance imaging was validated and detectability estimated using physiological noise recorded from the marmoset visual thalamus. The results..View full abstract
Awarded by Australian National Health & Medical Research Council
Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant)
The authors would like to acknowledge Natalie Zeater, Paul Martin, Alexsander Pietersen, and Xin Cheng for their assistance in providing the electrophysiological data and ex vivo histology. This work was supported by the Australian National Health & Medical Research Council Project grant number 1042609; the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007), and a Faculty of Engineering Mid Career Researcher Grant and the Australian Institute for Nanoscale Science and Technology at The University of Sydney. The authors declare no competing financial interests.