Journal article

Hypersensitivities following allergen antigen recognition by unconventional T cells

Marcela de Lima Moreira, Michael NT Souter, Zhenjun Chen, Liyen Loh, James McCluskey, Daniel G Pellicci, Sidonia BG Eckle

Allergy | WILEY | Published : 2020

Abstract

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti-microbial and anti-tumour immunity. Conventional T cells have also been implicated in type IV (also termed delayed-type or T cell-mediated) hypersensitivity reactions in response to protein-derived allergen antigens. In addition to conventional T cells, subsets of unconventional T cells exist, which recognise non-protein antigens in the context of monomorphic MHC class I-like molecules. These include T cells that are restricted to the cluster of differentiation 1 (CD1) family members, known as CD1-restricted T cells, and mucosal-ass..

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Grants

Awarded by Australian Research Council


Awarded by National Health and Medical Research Council


Awarded by Allergy and Immunology Foundation of Australasia (AIFA)


Funding Acknowledgements

CSL limited, Grant/Award Number: CSL Centenary Fellowship; Australian Government, Department of Education, Grant/Award Number: Australian Postgraduate Award; Australian Research Council, Grant/Award Number: DECRA (DE170100407); National Health and Medical Research Council, Grant/Award Number: NHMRC program grant (1113293); Allergy and Immunology Foundation of Australasia (AIFA), Grant/Award Number: 2019 AIFA grant