Journal article

Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2

Nichaela Harbison-Price, Scott A Ferguson, Adam Heikal, George Taiaroa, Kiel Hards, Yoshio Nakatani, David Rennison, Margaret A Brimble, Ibrahim M El-Deeb, Lisa Bohlmann, Christopher A McDevitt, Mark von Itzstein, Mark J Walker, Gregory M Cook

mSphere | AMER SOC MICROBIOLOGY | Published : 2020

Abstract

Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of antimicrobials used exclusively in animals, holds promise as a strategy to replace or reduce essential human antimicrobials in veterinary practice. PBT2 is a zinc ionophore with recently demonstrated antibacterial activity against several Gram-positive pathogens, although the underlying mechanism of action is unknown. Here, we investigated the bactericidal mechanism of PBT2 in the bovine mastitis-causing pa..

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Grants

Awarded by Ministry of Business, Innovation and Employment (MBIE) Endeavor Fund, New Zealand


Funding Acknowledgements

This work was supported by a research program grant (UOOX1603) from the Ministry of Business, Innovation and Employment (MBIE) Endeavor Fund, New Zealand. N.H.-P. was supported by a University of Otago Doctoral Scholarship and a Todd Foundation Award for Excellence. C.A.M., M.V.I., and M.J.W. were supported by funding from the National Health and Medical Research Council (NHMRC) Australia.