Journal article

Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study.

Antonia Valenzuela, Murray Baron, undefined Canadian Scleroderma Research Group, Ariane L Herrick, Susanna Proudman, Wendy Stevens, undefined Australian Scleroderma Interest Group, Tatiana S Rodriguez-Reyna, Alessandra Vacca, Thomas A Medsger, Monique Hinchcliff, Vivien Hsu, Joy Y Wu, David Fiorentino, Lorinda Chung

Semin Arthritis Rheum | Published : 2016


OBJECTIVES: We sought to identify the clinical factors associated with calcinosis in an international multicenter collaborative effort with the Scleroderma Clinical Trials Consortium (SCTC). METHODS: This is a retrospective cohort study of 5218 patients with systemic sclerosis (SSc). Logistic regression was used to obtain odds ratios (OR) relating calcinosis to various clinical features in multivariate analyses. RESULTS: A total of 1290 patients (24.7%) had calcinosis. In univariate analyses, patients with calcinosis were older than patients without calcinosis, more likely to be female, and had longer disease duration from the first non-Raynaud phenomenon symptom. Patients with calcinosis we..

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