Journal article

The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis

Leonardo Martinez, Olivia Cords, C Robert Horsburgh, Jason R Andrews, Carlos Acuna-Villaorduna, Shama Desai Ahuja, Neus Altet, Orvalho Augusto, Davit Baliashvili, Sanjay Basu, Mercedes Becerra, Maryline Bonnet, W Henry Boom, Martien Borgdorff, Fadila Boulahbal, Anna Cristina C Carvalho, Joan A Cayla, Tsira Chakhaia, Pei-Chun Chan, Ted Cohen Show all

The Lancet | Elsevier BV | Published : 2020

Abstract

Background Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood. Methods In this systematic review and meta-analysis, we investigated the development of tuberculosis in children closely exposed to a tuberculosis case and followed for incident disease. We restricted our search to cohort studies published between Jan 1, 1998, and April 6, 2018, in MEDLINE, Web of Science, BIOSIS, and Embase electronic databases. Individual-participant data and a pre-specified ..

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