Journal article

Ancestry-Specific Analyses Reveal Differential Demographic Histories and Opposite Selective Pressures in Modern South Asian Populations

Burak Yelmen, Mayukh Mondal, Davide Marnetto, Ajai K Pathak, Francesco Montinaro, Irene Gallego Romero, Toomas Kivisild, Mait Metspalu, Luca Pagani

MOLECULAR BIOLOGY AND EVOLUTION | OXFORD UNIV PRESS | Published : 2019

Abstract

Genetic variation in contemporary South Asian populations follows a northwest to southeast decreasing cline of shared West Eurasian ancestry. A growing body of ancient DNA evidence is being used to build increasingly more realistic models of demographic changes in the last few thousand years. Through high-quality modern genomes, these models can be tested for gene and genome level deviations. Using local ancestry deconvolution and masking, we reconstructed population-specific surrogates of the two main ancestral components for more than 500 samples from 25 South Asian populations and showed our approach to be robust via coalescent simulations. Our f3 and f4 statistics-based estimates reveal ..

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University of Melbourne Researchers

Grants

Awarded by European Union through the European Regional Development Fund


Awarded by European Union through Horizon 2020 grant


Awarded by Estonian Research Council grant PUT


Awarded by IUT of the Estonian Ministry of Education and Research


Funding Acknowledgements

This work was supported by the European Union through the European Regional Development Fund (project number 2014-2020.4.01.16-0024, MOBTT53: L.P., D.M., B.Y.; project number 2014-2020.4.01.15-0012: M.Me.; project no. 20142020.4.01.16-0030: B.Y., M.Mo., F.M.); the European Union through Horizon 2020 grant number 810645: M.Me.; the Estonian Research Council grant PUT (PRG243): M.Me., L.P.; institutional research funding IUT (IUT24-1) of the Estonian Ministry of Education and Research: A.K.P., T.K.; the European Social Fund's Doctoral Studies 25 and Internationalisation Programme DoRa: A.K.P.