Thrombus-Targeted Theranostic Microbubbles: A New Technology towards Concurrent Rapid Ultrasound Diagnosis and Bleeding-free Fibrinolytic Treatment of Thrombosis
Xiaowei Wang, Yannik Gkanatsas, Jathushan Palasubramaniam, Jan David Hohmann, Yung Chih Chen, Bock Lim, Christoph E Hagemeyer, Karlheinz Peter
Theranostics | IVYSPRING INT PUBL | Published : 2016
RATIONALE: Myocardial infarction and stroke are leading causes of morbidity/mortality. The typical underlying pathology is the formation of thrombi/emboli and subsequent vessel occlusion. Systemically administered fibrinolytic drugs are the most effective pharmacological therapy. However, bleeding complications are relatively common and this risk as such limits their broader use. Furthermore, a rapid non-invasive imaging technology is not available. Thereby, many thrombotic events are missed or only diagnosed when ischemic damage has already occurred. OBJECTIVE: Design and preclinical testing of a novel 'theranostic' technology for the rapid non-invasive diagnosis and effective, bleeding-fre..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by National Heart Foundation (NHF)
This work was funded by the National Health and Medical Research Council (NHMRC) project grant 1050018 (K.P.) and the National Heart Foundation (NHF) Grant-in-Aid G05M2134 (K.P.); an Australian Research Council Future Fellowship (K.P.), NHMRC Principal Research Fellowships (K.P.), NHF Career Development Fellowship (C.E.H) and a NHF Postdoctoral Fellowships (X.W. and YC.C.). Y.G was supported by a stipend from the Deutsche Herzstiftung. The study was supported in part by the Victorian Government's Operational Infrastructure Support Program.