Nicotine attenuates disruption of blood-brain barrier induced by saturated-fat feeding in wild-type mice

Abstract

Introduction: Emerging evidence suggests that integrity of blood-brain barrier (BBB) is pivotal to pathology and pathogenesis of vascular-based neurodegenerative disorders. We have recently reported BBB protective effects of nutraceutical agents with anti-inflammatory properties in an established dietary-induced BBB dysfunction model. Studies also reported that nicotine exhibits anti-oxidative/-inflammatory effects and improve cognitive impairment in Alzheimer's disease. However there has been no studies reporting the effect of nicotine on high-fat-induced BBB dysfunction. Methods: In the present study, we investigated the effect of nicotine on BBB integrity and neuroinflammation in an estab..