Journal article
GPVI and GPIBα mediate Staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors
H Hu, PCJ Armstrong, E Khalil, YC Chen, A Straub, M Li, J Soosairajah, CE Hagemeyer, N Bassler, D Huang, I Ahrens, G Krippner, E Gardiner, K Peter
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Background: Staphylococcus aureus (S. aureus) is a common pathogen capable of causing life-threatening infections. Staphylococcal superantigen-like protein 5 (SSL5) has recently been shown to bind to platelet glycoproteins and induce platelet activation. This study investigates further the interaction between SSL5 and platelet glycoproteins. Moreover, using a glycan discovery approach, we aim to identify potential glycans to therapeutically target this interaction and prevent SSL5-induced effects. Methodology/Principal Findings: In addition to platelet activation experiments, flow cytometry, immunoprecipitation, surface plasmon resonance and a glycan binding array, were used to identify spec..
View full abstractGrants
Funding Acknowledgements
This study was funded by the National Health & Medical Research Council (NHMRC) of Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.