The Antioxidant Moiety of MitoQ Imparts Minimal Metabolic Effects in Adipose Tissue of High Fat Fed Mice
Simon T Bond, Jisu Kim, Anna C Calkin, Brian G Drew
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2019
Mitochondrial dysfunction is associated with a diverse array of diseases ranging from dystrophy and heart failure to obesity and hepatosteatosis. One of the major biochemical consequences of impaired mitochondrial function is an accumulation of mitochondrial superoxide, or reactive oxygen species (ROS). Excessive ROS can be detrimental to cellular health and is proposed to underpin many mitochondrial diseases. Accordingly, much research has been committed to understanding ways to therapeutically prevent and reduce ROS accumulation. In white adipose tissue (WAT), ROS is associated with obesity and its subsequent complications, and thus reducing mitochondrial ROS may represent a novel strategy..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
We acknowledge funding support from the Victorian State Government OIS program to the Baker Heart and Diabetes Institute. This work was supported in part by a grant from the Australian National Health and Medical Research Council (NHMRC) to BD (APP1128060). BD and AC have been supported by the National Heart Foundation of Australia, Future Leader Fellowship Scheme.