Journal article
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
SK Merid, A Novoloaca, GC Sharp, LK Küpers, AT Kho, R Roy, L Gao, I Annesi-Maesano, P Jain, M Plusquin, M Kogevinas, C Allard, FO Vehmeijer, N Kazmi, LA Salas, FI Rezwan, H Zhang, S Sebert, D Czamara, SL Rifas-Shiman Show all
Genome Medicine | BMC | Published : 2020
Abstract
Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses o..
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Awarded by European Research Council
Funding Acknowledgements
This study was specifically funded by a grant from the European Research Council (TRIBAL, grant agreement 757919). For all studies, detailed information can be found in Additional file 2: Supplementary information. Open access funding provided by Uppsala University.