Journal article

Both high and low HCG day progesterone concentrations negatively affect live birth rates in IVF/ICSI cycles

Philippe Arvis, Philippe Lehert, Anne Guivarc'h-Leveque

Reproductive BioMedicine Online | ELSEVIER SCI LTD | Published : 2019

Abstract

RESEARCH QUESTION: Can previous reports of a decreased probability of success in stimulated IVF cycles with premature rise of progesterone, as determined by progesterone concentration on HCG day (PHCG), be confirmed? DESIGN: Retrospective, observational, single-centre cohort study conducted on 5447 IVF and intracytoplasmic (ICSI) cycles carried out among 2192 patients between 2009 and 2015, with conventional ovarian stimulation. This large database was used to develop a non-linear mixed prognosis model of live birth rate (LBR) incorporating PHCG as a predictor. RESULTS: In addition to known predictors (age, body mass index, anti-Müllerian hormone, type of infertility), PHCG was associated wi..

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