Journal article

Association of brachial-cuff excess pressure with carotid intima-media thickness in Australian adults: a cross-sectional study

Xiaoqing Peng, Melissa Wake, Martin G Schultz, David P Burgner, Petr Otahal, Jonathan P Mynard, Susan Ellul, Michael Cheung, Richard S Liu, Markus Juonala, James E Sharman

Journal of Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

OBJECTIVE: Reservoir pressure parameters [e.g. reservoir pressure (RP) and excess pressure (XSP)] measured using tonometry predict cardiovascular events beyond conventional risk factors. However, the operator dependency of tonometry impedes widespread use. An operator-independent cuff-based device can reasonably estimate the intra-aortic RP and XSP from brachial volumetric waveforms, but whether these estimates are clinically relevant to preclinical phenotypes of cardiovascular risk has not been investigated. METHODS: The RP and XSP were derived from brachial volumetric waveforms measured using cuff oscillometry (SphygmoCor XCEL) in 1691 mid-life adults from the CheckPoint study (a populatio..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by Future Leader Fellowship of the National Heart Foundation of Australia


Funding Acknowledgements

This work has been supported by the National Health and Medical Research Council of Australia (1041352, 1109355), the Royal Children's Hospital Foundation (2014-241), Murdoch Childrens Research Institute, the University of Melbourne, National Heart Foundation of Australia (100660), Financial Markets Foundation for Children (2014-055). The funding bodies did not play any role in the study. The following authors were supported by the National Health and Medical Research Council of Australia: Early Career Fellowship (1104731) to M.G.S. Wright Career Development Fellowship (1143510) to J.M., Senior Research Fellowships (1046518) to M.W. and (1064629) to D.P.B., Postgraduate Research Scholarship (1114567) to R.L., Career Development Fellowship (409940) to J.S. M.W. was also supported by Cure Kids, New Zealand, and D.B. and J.M. were also supported by Future Leader Fellowship of the National Heart Foundation of Australia (100369 and 101866). M.J. was supported by the Federal Research Grant of Finland to Turku University Hospital, Finnish Cardiovascular Foundation.