Journal article

Social skills and autism spectrum disorder symptoms in children with neurofibromatosis type 1: evidence for clinical trial outcomes

Jonathan M Payne, Karin S Walsh, Natalie A Pride, Kristina M Haebich, Alice Maier, Anita Chisholm, Danielle M Glad, Christina L Casnar, Melissa Rouel, Jennifer Lorenzo, Allison Del Castillo, Kathryn N North, Bonita Klein-Tasman

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | WILEY | Published : 2020

Abstract

AIM: We examined key features of two outcome measures for social dysfunction and autism spectrum disorder traits, the Social Responsiveness Scale, Second Edition (SRS-2) and the Social Skills Improvement System - Rating Scales (SSIS-RS), in children with neurofibromatosis type 1 (NF1). The aim of the study was to provide objective evidence as to which behavioural endpoint should be used in clinical trials. METHOD: Cross-sectional behavioural and demographic data were pooled from four paediatric NF1 tertiary referral centres in Australia and the United States (N=122; 65 males, 57 females; mean age [SD] 9y 2mo [3y], range 3-15y). RESULTS: Distributions of SRS-2 and SSIS-RS scores were unimodal..

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