Development and Validation of a Penicillin Allergy Clinical Decision Rule

Jason A Trubiano; Sara Vogrin; Kyra YL Chua; Jack Bourke; James Yun; Abby Douglas; Cosby A Stone; Roger Yu; Lauren Groenendijk; Natasha E Holmes; Elizabeth J Phillips

Journal article

Development and Validation of a Penicillin Allergy Clinical Decision Rule

Jason A Trubiano, Sara Vogrin, Kyra YL Chua, Jack Bourke, James Yun, Abby Douglas, Cosby A Stone, Roger Yu, Lauren Groenendijk, Natasha E Holmes, Elizabeth J Phillips

JAMA INTERNAL MEDICINE | AMER MEDICAL ASSOC | Published : 2020

DOI: 10.1001/jamainternmed.2020.0403

Abstract

Importance: Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and health services. Validated clinical decision rules are urgently needed to identify low-risk penicillin allergies that potentially do not require penicillin skin testing by a specialist. Objective: To develop and validate a penicillin allergy clinical decision rule that enables point-of-care risk assessment of patient-reported penicillin allergies. Design, Setting, and Participants: In this diagnostic study, a multicenter prospective antibiotic allergy-tested cohort of 622 patients from 2 tertiary care sites in Melbourne, Australia (Austin Health and Peter MacCallum Cancer..

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University of Melbourne Researchers

Kyra Chua Author Microbiology and Immunology

Sara Vogrin Author Medicine - St Vincent's Hospital

Jason Trubiano Author Medicine - Austin Health

Natasha Holmes Author Critical Care

Abby Douglas Author The Sir Peter Maccallum Department of Oncology

Related Projects (1)

DEVELOPING AND EVALUATING A MULTIMODAL ANTIBIOTIC ALLERGY STRATEGY TO IMPROVE ANTIMICROBIAL STEWARDSHIP IN HIGH-RISK ANTIBIOTIC USAGE POPULATIONS

Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of ..

Grants

Awarded by NHMRC

Awarded by NIH

Awarded by AHRQ

Funding Acknowledgements

This study was supported by a grant from the Austin Medical Research Foundation (AMRF); postgraduate scholarship GNT 1139902 from the NHMRC (Dr Trubiano); a postgraduate scholarship from the National Centre for Infections in Cancer (Dr Trubiano); grants 1P50GM115305-01, R21AI139021, R34AI136815, and 1R01HG01086301 from the NIH (Dr Phillips); the NHMRC (Dr Phillips); and grant 1K12HS026395-01 from the AHRQ (Dr Stone).