Journal article

Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography

Kathryn S Stok, Andrew J Burghardt, Stephanie Boutroy, Michiel PH Peters, Sarah L Manske, Vincent Stadelmann, Nicolas Vilayphiou, Joop P van den Bergh, Piet Geusens, Xiaojuan Li, Hubert Marotte, Bert van Rietbergen, Steven K Boyd, Cheryl Barnabe

Quantitative imaging in medicine and surgery | AME Publishing Company | Published : 2020


Background: Joint space assessment for rheumatoid arthritis (RA) by ordinal conventional radiographic scales is susceptible to floor and ceiling effects. High-resolution peripheral quantitative computed tomography (HR-pQCT) provides superior resolution, and may detect earlier changes. The goal of this work was to compare existing 3D methods to calculate joint space width (JSW) metrics in human metacarpophalangeal (MCP) joints with HR-pQCT and reach consensus for future studies. Using the consensus method, we established reproducibility with repositioning as well as feasibility for use in second-generation HR-pQCT scanners. Methods: Three published JSW methods were compared using datasets fr..

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University of Melbourne Researchers