Journal article

Health-related quality-of-life in children with cystic fibrosis aged 5-years and associations with health outcomes

Joyce Cheney, Suzanna Vidmar, Nicholas Gailer, Claire Wainwright, Tonia A Douglas

JOURNAL OF CYSTIC FIBROSIS | ELSEVIER | Published : 2020

Abstract

BACKGROUND: The impact of early cystic fibrosis (CF) on health-related quality-of-life (HRQOL) in preschool children is poorly characterised, and data on relationships between HRQOL and health outcomes in young children with CF are limited. We aimed to characterise and compare parent-proxy and child-reported HRQOL and evaluate relationships with clinical outcomes at age 5-years. METHODS: Subjects were participating in the multi-centre Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) trial investigating BAL-directed versus standard CF therapy. Children aged 5-years and their parents rated HRQOL using the Pediatric Quality of Life Inventory (PedsQL™) and Cystic Fibrosis Questionnai..

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Grants

Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (grant numbers 9937868 and 351541) and the Children's Hospital Foundation Queensland, Australia. The tobramycin inhalation solution and delivery system used throughout the ACFBAL study was supplied by Pathogenesis Corporation, Chiron Corporation, and Novartis Pharmaceuticals Inc. CW was supported by a project grant from the Children's Hospital Foundation Brisbane and a Queensland Health Research Fellowship.