Journal article

Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study

Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis

npj Schizophrenia | Springer Nature | Published : 2020

Abstract

Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in children (SDc) is less well described. This study examined brain morphological and functional connectivity abnormalities in SDc (12 SDc and 9 typically developing children), focusing on the default mode and executive control brain networks. Results indicated that SDc is associated with reduced grey matter volume (GMV) in superior and medial frontal gyri, and increased resting-state functional connectivity between the superior frontal gyrus and inferior parietal lobule, compared to typically developing children (cluster-level FWE-corrected p < 0.05). The brain structure ..

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Grants

Awarded by University of Melbourne Research Grant Support Scheme


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US)


Awarded by Lundbeck Foundation


Awarded by NHMRC Early Career Fellowship


Funding Acknowledgements

Support for this pilot study was provided by a grant from The University of Melbourne Research Grant Support Scheme (ID: 1452755). Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US; Grant ID: 18722) and by a grant from the Lundbeck Foundation (ID: R246-2016-3237); Ian Harding was supported by an NHMRC Early Career Fellowship (ID: 1106533); Ya Wang was supported by China Scholarship Council. The authors thank the children and their families for their participation in this study. In addition, we thank Antonia Merritt and Annabel Burnside for assisting with recruitment. We thank the staff at the Imaging Facility at the Murdoch Children's Research Institute for support with the study, and Chester Kang at MNC for IT support.