Journal article

What type of exercise is most effective for people with knee osteoarthritis and co-morbid obesity?: The TARGET randomized controlled trial

KL Bennell, RK Nelligan, AJ Kimp, S Schwartz, J Kasza, TV Wrigley, B Metcalf, PW Hodges, RS Hinman

Osteoarthritis and Cartilage | ELSEVIER SCI LTD | Published : 2020

Abstract

OBJECTIVE: Different exercise types may yield different outcomes in osteoarthritis (OA) subgroups. The objective was to directly compare effectiveness of two exercise programs for people with medial knee OA and co-morbid obesity. DESIGN: We performed a participant- and assessor-blinded randomized controlled trial. 128 people ≥50 years with medial knee OA and body mass index ≥30 kg/m2 were recruited from the community. Interventions were home-based non-weight bearing (NWB) quadriceps strengthening or weight bearing (WB) functional exercise for 12 weeks. Primary outcomes were change in overall knee pain (numeric rating scale, range 0-10) and difficulty with physical function (Western Ontario a..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (NHMRC) Program Grant #1091302. KLB is supported by a NHMRC Principal Research Fellowship (1058440). PWH is supported by a NHMRC Senior Principal Research Fellowship (1102905). RSH is supported by a National Health and Medical Research Council Fellowship (#1154217). Funders had no role in design and conduct of the study; collection, management, data analysis, and interpretation; and preparation, review, or approval of the manuscript or the decision to submit for publication.