Effects of gender-affirming hormone therapy on insulin resistance and body composition in transgender individuals: A systematic review
Cassandra Spanos, Ingrid Bretherton, Jeffrey D Zajac, Ada S Cheung
WORLD JOURNAL OF DIABETES | BAISHIDENG PUBLISHING GROUP INC | Published : 2020
BACKGROUND: Transgender individuals receiving masculinising or feminising gender-affirming hormone therapy with testosterone or estradiol respectively, are at increased risk of adverse cardiovascular outcomes, including myocardial infarction and stroke. This may be related to the effects of testosterone or estradiol therapy on body composition, fat distribution, and insulin resistance but the effect of gender-affirming hormone therapy on these cardiovascular risk factors has not been extensively examined. AIM: To evaluate the impact of gender-affirming hormone therapy on body composition and insulin resistance in transgender individuals, to guide clinicians in minimising cardiovascular risk...View full abstract
Awarded by Australian Government National Health and Medical Research Council
Awarded by Viertel Charitable Foundation Clinical Investigator Award
Supported by Australian Government National Health and Medical Research Council, No. APP1143333; Endocrine Society of Australia; Austin Medical Research Foundation; Viertel Charitable Foundation Clinical Investigator Award, No. VIERCI2017009; Royal Australasian College of Physicians Vincent Fairfax Family Foundation.