Journal article

Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes

Matteo Bruschettini, Colm PF O'Donnell, Peter G Davis, Colin J Morley, Lorenzo Moja, Maria Grazia Calevo

Cochrane Database of Systematic Reviews | WILEY | Published : 2020


BACKGROUND: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable gas exchange. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volume within the lungs. OBJECTIVES: To assess the benefits and harms of an initial sustained lung inflation (SLI) (> 1 second duration) versus standard inflations (≤ 1 second) in newborn infants receiving resuscitation with intermittent PPV. SEARCH METHODS: We used the standard search strategy of Cochrane Neo..

View full abstract


Funding Acknowledgements

Internal sourcesInstitute for Clinical Sciences, Lund University; Research & Development, Skane University Hospital, Lund, Sweden.MB is employed by this organizationRoyal Women's Hospital, Melbourne, Australia.PD is employed by this organizationUniversity of Melbourne, Australia.PD is employed by this organizationIstituto Giannina Gaslini, Genoa, Italy.MGC is employed by this organizationExternal sourcesMurdoch Children's Research Institute, Australia.PD is employed by this organizationNational Health and Medical Research Council, Australia.PD is employed by this organizationVermont Oxford Network, USA.Cochrane Neonatal Reviews are produced with support from Vermont Oxford Network, a worldwide collaboration of health professionals dedicated to providing evidence-based care of the highest quality for newborn infants and their families.