Journal article

The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis

Engku Anis Fariha Enguku Nasrullah Satiman, Hasna Ahmad, Ahmad Bazli Ramzi, Ridhwan Abdul Wahab, Mohd Arifin Kaderi, Wan Himratul Aznita Wan Harun, Stuart Dashper, Michael McCullough, Mohd Hafiz Arzmi

Journal Of Oral Pathology and Medicine | WILEY | Published : 2020

Abstract

Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and progression of oral cancer. C albicans invasion induces several cancerous hallmarks, such as activation of proto-oncogenes, induction of DNA damage and overexpression of inflammatory signalling pathways. However, the molecular mechanisms behind these responses remain unclear. A recently discovered fungal toxin peptide, candidalysin, has been reported as an essential molecule in epithelial damage a..

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