Quality of life after breast-conserving therapy and adjuvant radiotherapy for non-low-risk ductal carcinoma in situ (BIG 3-07/TROG 07.01): 2-year results of a randomised, controlled, phase 3 trial

MT King; EK Link; TJ Whelan; IA Olivotto; I Kunkler; AH Westenberg; G Gruber; P Schofield; BH Chua; C Phillips; G Bryant; H Westenberg; OPK Purohit; V Ahern; P Graham; M Akra; O McArdle; P O'Brien; J Ludbrook; J Harvey; JH Maduro; I Gabelle-Flandin; C Kirkove; C Bedi; J Martin; T Vu; T Muanza; A Neal; A Courdi; J Thariat; E Rakovitch; L Daniels; M van Hezewijk; W Cwajna; A Roelstraete; A van Baardwijk; N Russel; A Koch; J Croke; I Locke; P Jeal; Q Walker; K Thuraisingham; A Chauduri; D Joseph; M Taylor; S Vanderkam; T Woo; J Tang; M Yassa; E Wai; S Hewitt; S Mahmood; J Gilmore; B Ofi; A Bahl; O Vujovic; E Yu; D Le; I Kong; A Nichol; N Bijker; G Delaney; M Feigen; A Lim; M Chao; M Latham; H Algurafi; C Tausch; E Khoo; S Leung; K Taylor; S Senthi; A Stevens; A Chaudhuri; S Cleator; AM Brunt; S Babington; D Christie; D Zwahlen; U Schratzenstaller; L Masson; N Storey; E Kumar; L Sherwin; R Weytjens; S Ravi; P Lawton; R Angell; G Round; A Allen; Z Thotathil; M Anthes; C Reuter; L Pettit; Y Zissiadis; C Elder; A Verbeek-de Kanter; A Lirette; L Plasswilm

Journal article

Quality of life after breast-conserving therapy and adjuvant radiotherapy for non-low-risk ductal carcinoma in situ (BIG 3-07/TROG 07.01): 2-year results of a randomised, controlled, phase 3 trial

MT King, EK Link, TJ Whelan, IA Olivotto, I Kunkler, AH Westenberg, G Gruber, P Schofield, BH Chua, C Phillips, G Bryant, H Westenberg, OPK Purohit, V Ahern, P Graham, M Akra, O McArdle, P O'Brien, J Ludbrook, J Harvey Show all

Lancet Oncology | ELSEVIER SCIENCE INC | Published : 2020

DOI: 10.1016/S1470-2045(20)30085-1

Abstract

Background: BIG 3-07/TROG 07.01 is an international, multicentre, randomised, controlled, phase 3 trial evaluating tumour bed boost and hypofractionation in patients with non-low-risk ductal carcinoma in situ following breast-conserving surgery and whole breast radiotherapy. Here, we report the effects of diagnosis and treatment on health-related quality of life (HRQOL) at 2 years. Methods: The BIG 3-07/TROG 07.01 trial is ongoing at 118 hospitals in 11 countries. Women aged 18 years or older with completely excised non-low-risk ductal carcinoma in situ were randomly assigned, by use of a minimisation algorithm, to tumour bed boost or no tumour bed boost, following conventional whole breast ..

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