Journal article

Brain compensation during response inhibition in premanifest Huntington's disease

Maria Soloveva, Sharna D Jamadar, Matthew Hughes, Dennis Velakoulis, Govinda Poudel, Nellie Georgiou-Karistianis

BRAIN AND COGNITION | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

Premanifest Huntington's disease (pre-HD) individuals typically show increased task-related functional magnetic resonance imaging (fMRI), suggested to reflect compensatory strategies. Despite the evidence, no study has attempted to understand the compensatory process in light of 'formal' models of compensation. We used a quantitative model of compensation - the Compensation-Related Utilization of Neural Circuits Hypothesis (CRUNCH), to characterise compensation in pre-HD using fMRI. Pre-HD individuals (n = 15) and controls (n = 15) performed a modified stop-signal task that incremented in four levels of stop difficulty. Our results did not support the critical assumption of the CRUNCH model ..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council (ARC)


Awarded by ARC Centre of Excellence for Integrative Brain Function


Funding Acknowledgements

Jamadar is supported by an Australian Research Council (ARC) Discovery Early Career Research Award (DE150100406) and the ARC Centre of Excellence for Integrative Brain Function (CE140100007).Poudel was supported by the Hereditary Disease Foundation USA Fellowship and Huntington's Disease Association (NSW).