Journal article

Renovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms

Mariana Rosso Melo, Silvia Gasparini, Elaine F Silva, Marlusa Karlen-Amarante, Guilherme F Speretta, Mariana R Lauar, Gustavo R Pedrino, Jose Menani, Debora SA Colombari, Daniel B Zoccal, Eduardo Colombari

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2020

Abstract

The two kidney-one clip (2K1C) renovascular hypertension depends on the renin-angiotensin system and sympathetic overactivity. The maintenance of 2K1C hypertension also depends on inputs from the carotid bodies (CB), which when activated stimulate the respiratory activity. In the present study, we investigated the importance of CB afferent activity for the ventilatory responses in 2K1C hypertensive rats and for phrenic and hypoglossal activities in in situ preparations of normotensive rats treated with angiotensin II. Silver clips were implanted around the left renal artery of male Holtzman rats (150 g) to induce renovascular hypertension. Six weeks after clipping, hypertensive 2K1C rats sho..

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Grants

Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)


Awarded by Sao Paulo Research Foundation (FAPESP)


Funding Acknowledgements

This research was supported by Brazilian public funding from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Grant 310331/2017-0; 449392/2014-7) and Sao Paulo Research Foundation (FAPESP, Grants 2014/01159-6, 2013/17.251-6, and 2015/23467-7).