Journal article

Normal Gamma Glutamyl Transferase Levels at Presentation Predict Poor Outcome in Biliary Atresia

Sahana Shankar, Rishi Bolia, Hee Wei Foo, Colleen E D'Arcy, Natasha Hardikar, Martin Wensing, Winita Hardikar

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

OBJECTIVES: Gamma-glutamyl transferase levels (GGT) are typically elevated in biliary atresia (BA), but normal GGT levels have been observed. This cohort of "normal GGT" BA has neither been described nor has the prognostic value of GGT level on outcomes in BA. We aimed to describe outcomes of a single-centre Australian cohort of infants with BA and assess the impact of GGT level at presentation on outcomes in BA. METHODS: Infants diagnosed with BA between 1991 and 2017 were retrospectively analysed. Outcomes were defined as survival with native liver, liver transplantation (LT), and death. Patients were categorized into normal (<200I U/L) or high GGT groups based on a mean of 3 consecutive G..

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