Beyond the Brain: Peripheral Interactions after Traumatic Brain Injury
Stuart J McDonald, Jessica M Sharkey, Mujun Sun, Lola M Kaukas, Sandy R Shultz, Renee J Turner, Anna Leonard, Rhys D Brady, Frances Corrigan
Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2020
Traumatic brain injury (TBI) is a leading cause of death and disability, and there are currently no pharmacological treatments known to improve patient outcomes. Unquestionably, contributing toward a lack of effective treatments is the highly complex and heterogenous nature of TBI. In this review, we highlight the recent surge of research that has demonstrated various central interactions with the periphery as a potential major contributor toward this heterogeneity and, in particular, the breadth of research from Australia. We describe the growing evidence of how extracranial factors, such as polytrauma and infection, can significantly alter TBI neuropathology. In addition, we highlight how ..View full abstract
Awarded by National Health and Medical Research Council
This work was supported by funding from the Neurosurgical Research Foundation and the National Health and Medical Research Council (APP1145483).