Journal article

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

Yuhao Jiao, Li Wu, Nicholas D Huntington, Xuan Zhang

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2020

Abstract

The emerging concept of microbiota contributing to local mucosal homeostasis has fueled investigation into its specific role in immunology. Gut microbiota is mostly responsible for maintaining the balance between host defense and immune tolerance. Dysbiosis of gut microbiota has been shown to be related to various alterations of the immune system. This review focuses on the reciprocal relationship between gut microbiota and innate immunity compartment, with emphasis on gut-associated lymphoid tissue, innate lymphoid cells, and phagocytes. From a clinical perspective, the review gives a possible explanation of how the "gut microbiota-innate immunity" axis might contribute to the pathogenesis ..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by Chinese Academy of Medical Science Innovation Fund for Medical Sciences


Awarded by National Key Research and Development Program: Precise Medical Research


Awarded by Ministry of Science and Technology of China


Funding Acknowledgements

XZ was supported by grants from the National Natural Science Foundation of China (81788101, 81630044, 81601432, 81550023, 81771763, 91542000), Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFMS2016-12M-1003, 2017-12M-1-008, 2017-I2M-3-011, 2016-12M-1-008), and National Key Research and Development Program: Precise Medical Research (2016YFC0903900). LW was supported by the Key Project Grants from the National Natural Science Foundation of China (Nos. 31330027 and 91642207), a National Key Research Project Grant from the Ministry of Science and Technology of China (No. 2015CB943200).