Journal article
Patient Outcomes at Twelve Months after Early Decompressive Craniectomy for Diffuse Traumatic Brain Injury in the Randomized DECRA Clinical Trial.
D James Cooper, Jeffrey V Rosenfeld, Lynnette Murray, Yaseen M Arabi, Andrew R Davies, Jennie Ponsford, Ian Seppelt, Peter Reilly, Eveline Wiegers, Rory Wolfe, undefined DECRA Trial Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group
J Neurotrauma | Published : 2020
Abstract
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial, patients were randomly allocated 1:1 to either early decompressive craniectomy or intensive medical therapies (standard care). We conducted planned secondary analyses of the DECRA trial outcomes at 6 and 12 months, including all 155 patients. We measured functional outcome using the Glasgow Outcome Scale-Extended (GOS-E). We used ordered logistic regression, and dichotomized the GOS-E using logistic regression, to assess outcomes in patients overall and in surviv..
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