Journal article
PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers
JH Lee, JS Liow, S Paul, CL Morse, MB Haskali, L Manly, S Shcherbinin, JC Ruble, N Kant, EC Collins, HN Nuthall, P Zanotti-Fregonara, SS Zoghbi, VW Pike, RB Innis
Ejnmmi Research | SPRINGER | Published : 2020
Abstract
Background: Previous studies found that [18F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate the suitability of [18F]LSN3316612 for human clinical research. Methods: Kinetic evaluation of [18F]LSN3316612 was conducted in a combined set of baseline brain scans from 17 healthy human volunteers and test-retest imaging was conducted in 10 of these volunteers; another 6 volunteers had whole-body scans to measure radiation exposure to body organs. Total distribution volume (VT) estimates were compared for the one- and two-tissue compartment models with the arterial inp..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported jointly by the Intramural Research Program of the National Institute of Mental Health, National Institutes of Health (NIMH; project numbers ZIAMH002793 and ZIAMH002852), and a Cooperative Research and Development Agreement (CRADA) with Eli Lilly and Co.