Retinal Vessel Analysis as a Novel Screening Tool to Identify Childhood Acute Lymphoblastic Leukemia Survivors at Risk of Cardiovascular Disease
Mohamad S Azanan, Sudhashini Chandrasekaran, Erda S Rosli, Ling Ling Chua, Lixian Oh, Tong Foh Chin, Tsiao Yi Yap, Revathi Rajagopal, Reena Rajasuriar, Tom MacGillivray, Emanuele Trucco, Norlina Ramli, Tengku A Kamalden, Hany Ariffin
Journal of Pediatric Hematology/Oncology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
BACKGROUND: Microvascular endothelial dysfunction is central to the pathogenesis of cardiovascular disease (CVD). The eye offers direct access for endothelial health assessment via the retinal microvasculature. The aim of the study was to investigate whether image-based retinal vessel analysis is a feasible method of assessing endothelial health in survivors of childhood acute lymphoblastic leukemia (cALL). MATERIALS AND METHODS: Cardiovascular risk factors (CRFs) were estimated using the 30-year Framingham Risk Score in 73 childhood leukemia survivors (median age: 25; median years from diagnosis: 19) and 78 healthy controls (median age: 23). Radial arterial stiffness was measured using puls..View full abstract
Awarded by Ministry of Education, Malaysia
Awarded by University of Malaya
Awarded by EPSRC
Establishment of the Childhood Cancer Survivor Cohort at University of Malaya was supported by the Ministry of Education, Malaysia (UM. C/HIR/MOHE/MED/12). This study was partially funded by University of Malaya Research Grant (UMRG 049-17HTM). The VAMPIRE team acknowledges the support of EPSRC grant EP/M005976/1 "Multimodal retinal biomarkers for vascular dementia".