Journal article

Neurodegenerative pathways as targets for acquired epilepsy therapy development

Pablo M Casillas-Espinosa, Idrish Ali, Terence J O'Brien

Epilepsia Open | Wiley Open Access | Published : 2020

Abstract

There is a growing body of clinical and experimental evidence that neurodegenerative diseases and epileptogenesis after an acquired brain insult may share common etiological mechanisms. Acquired epilepsy commonly develops as a comorbid condition in patients with neurodegenerative diseases such as Alzheimer's disease, although it is likely much under diagnosed in practice. Progressive neurodegeneration has also been described after traumatic brain injury, stroke, and other forms of brain insults. Moreover, recent evidence has shown that acquired epilepsy is often a progressive disorder that is associated with the development of drug resistance, cognitive decline, and worsening of other neurop..

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Grants

Awarded by National Institute of Neurological Disorders and Stroke (NINDS) Centers without Walls


Awarded by NHMRC


Funding Acknowledgements

PMCE and IA were funded by Melbourne University Early Career Research Grant. This work was supported by the National Institute of Neurological Disorders and Stroke (NINDS) Centers without Walls [grant number U54 NS100064], a NHMRC Program Grant to TOB (#APP1091593), and The NHMRC Peter Doherty Early Career Fellowship to PMCE (#APP1166170).