Utilising Glycobiology for Fluorescent Nanodiamond Uptake and Imaging in the Central Nervous System
Lindsay M Parker, Philipp Reineck, Mina Ghanimi-Fard, Emma R Wilson, Sameera Iqbal, Michael Baratta, Nicole M Cordina, Anna Guller, Annemarie Nadort, Brant Gibson, Nicolle H Packer
2019 PHOTONICS & ELECTROMAGNETICS RESEARCH SYMPOSIUM - SPRING (PIERS-SPRING) | IEEE | Published : 2019
Nanodiamonds are a carbon based class of nanoparticle quickly gaining popularity due to their low toxicity and versatile applications in biology and nanomedicine Their cheap and large scale synthesis, extensive optical characterisation and ease of bio-functionalisation also makes nanodiamonds an attractive material for use in bio-targeting studies Although central nervous system (CNS) cells are well known to functionally communicate via electrical and chemical signals, cell-surface glycans mediate the initial contact between cells and exogenous proteins. Glycosylation, the enzymatic process by which glycans are attached to proteins and lipids, is the most abundant and functionally important ..View full abstract
Awarded by Australian Research Council (ARC) Centre of Excellence Scheme through the Centre of Excellence for Nanoscale BioPhotonics
Awarded by Australian Research Council Discovery Early Career Research Award
This work is primarily supported by the Australian Research Council (ARC) Centre of Excellence Scheme through the Centre of Excellence for Nanoscale BioPhotonics (CE140100003). LMP is supported by an Australian Research Council Discovery Early Career Research Award (Project Number: DE180100206) as well as Macquarie University Research Centre for Diamond Science and Technology and the Macquarie University Primary Carer Conference Support Scheme.