Journal article

Spatiotemporal patterns of high-frequency activity (80-170 Hz) in long-term intracranial EEG

Zhuying Chen, David Grayden, Anthony Burkitt, Udaya Seneviratne, Wendyl D’Souza, Chris French, Philippa Karoly, Katrina Dell, Mark Cook, Matias Maturana

Cold Spring Harbor Laboratory | Published : 2020


Objective To assess the variability in the rates and locations of high-frequency activity (HFA) and epileptiform spikes after electrode implantation, and to examine the long-term patterns of HFA using ambulatory intracranial EEG (iEEG) recordings. Methods Continuous iEEG recordings obtained over an average of 1.4 years from 15 patients with drug-resistant focal epilepsy were used in this study. HFA was defined as high-frequency events with amplitudes clearly larger than the background, which was automatically detected using a custom algorithm. High-frequency oscillations (HFOs) were also visually annotated by three neurologists in randomly sampled segments of the total data. The automaticall..

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