Journal article

Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.

Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso

Journal of Materials Chemistry B | Royal Society of Chemistry | Published : 2020


Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many applications in catalysis, bioanalytical sensing and nanomedicine. Herein, we report the engineering of multifunctional hybrid films by assembling adhesive biological nanoparticles composed of lipoate-conjugated phytoglycogen (L-PG). These nano building blocks possess adhesive properties, arising from their amphiphilic nature, and reactive functional disulfide groups. The assembly of L-PG on surfaces enabled the rapid and conformal deposition of a thin film on substrates of varying chemical composition and wettability. The L-PG films showed negligible cytotoxicity and modera..

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Awarded by Australian Research Council

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was funded by an Australian Research Council (ARC) Future Fellowship (F. Cavalieri, FT140100873) and a National Health and Medical Research Council Senior Principal Research Fellowship (F. Caruso, GNT1135806). This project received funding from the European Union Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 690901 (“Nanosupremi”) and no. 798565 (A. Amodio “RE-IMMUNE”). This work was performed at the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and in part at the Materials Characterization and Fabrication Platform (MCFP) at The University of Melbourne.