Journal article

Psychosocial Intervention With or Without Antipsychotic Medication for First-Episode Psychosis: A Randomized Noninferiority Clinical Trial

Shona M Francey, Brian O’Donoghue, Barnaby Nelson, Jessica Graham, Lara Baldwin, Hok Pan Yuen, Melissa J Kerr, Aswin Ratheesh, Kelly Allott, Mario Alvarez-Jimenez, Alex Fornito, Susy Harrigan, Andrew D Thompson, Stephen Wood, Michael Berk, Patrick D McGorry

Schizophrenia Bulletin Open | Oxford University Press (OUP) | Published : 2020


Abstract This triple-blind (participants, clinicians, and researchers) randomized controlled noninferiority trial examined whether intensive psychosocial intervention (cognitive-behavioral case management, CBCM) for first-episode psychosis (FEP) in 15–25 year-olds managed in a specialized early intervention for psychosis service was noninferior to usual treatment of antipsychotic medication plus CBCM delivered during the first 6 months of treatment. To maximize safety, participants were required to have low levels of suicidality and aggression, a duration of untreated psychosis (DUP) of less than 6 months, and be living in stable accommodation with social support. The primary ..

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