Journal article

Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank

Kelli Lehto, Sara Hagg, Donghao Lu, Robert Karlsson, Nancy L Pedersen, Miriam A Mosing

BIOLOGICAL PSYCHIATRY | ELSEVIER SCIENCE INC | Published : 2020

Abstract

BACKGROUND: Being adopted early in life, an indicator of exposure to early-life adversity, has been consistently associated with poor mental health outcomes in adulthood. Such associations have largely been attributed to stressful environments, e.g., exposure to trauma, abuse, or neglect. However, mental health is substantially heritable, and genetic influences may contribute to the exposure to childhood adversity, resulting in potential genetic confounding of such associations. METHODS: Here, we explored associations between childhood adoption and mental health-related outcomes in midlife in 243,797 UK Biobank participants (n adopted = 3151). We used linkage disequilibrium score regression ..

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Grants

Awarded by Swedish FORTE Grant


Awarded by Swedish Research Council


Awarded by Loo and Hans Osterman Foundation for Medical Research Grant


Awarded by European Regional Development Fund, programme Mobilitas Pluss, Estonia


Funding Acknowledgements

This work was supported by Swedish FORTE Grant No. 2013-2292 (to NLP), Swedish Research Council Grant Nos. 521-2013-8689 (to NLP) and 2015-03255 (to NLP), and Loo and Hans Osterman Foundation for Medical Research Grant Nos. 2017-00103 (to KL) and 2018-0004 (to MM), and the European Regional Development Fund, programme Mobilitas Pluss, Estonia, Grant No. MOBTP142 (to KL).