Journal article
International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients
J Teras, HM Kroon, JT Miura, T Kenyon-Smith, GM Beasley, D Mullen, NE Farrow, PJ Mosca, MC Lowe, CR Farley, A Potdar, H Daou, J Sun, M Carr, JM Farma, MA Henderson, D Speakman, J Serpell, KA Delman, BM Smithers Show all
Annals of Surgical Oncology | SPRINGER | Published : 2020
Abstract
Background: Isolated limb infusion (ILI) is used to treat in-transit melanoma metastases confined to an extremity. However, little is known about its safety and efficacy in octogenarians and nonagenarians (ON). Patients and Methods: ON patients (≥ 80 years) who underwent a first ILI for American Joint Committee on Cancer seventh edition stage IIIB/IIIC melanoma between 1992 and 2018 at nine international centers were included and compared with younger patients (< 80 years). A cytotoxic drug combination of melphalan and actinomycin-D was used. Results: Of the 687 patients undergoing a first ILI, 160 were ON patients (median age 84 years; range 80–100 years). Compared with the younger cohort (..
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