Journal article

International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients

Jueni Teras, Hidde M Kroon, John T Miura, Tim Kenyon-Smith, Georgia M Beasley, Dean Mullen, Norma E Farrow, Paul J Mosca, Michael C Lowe, Clara R Farley, Aishwarya Potdar, Hala Daou, James Sun, Michael Carr, Jeffrey M Farma, Michael A Henderson, David Speakman, Jonathan Serpell, Keith A Delman, B Mark Smithers Show all

Annals of Surgical Oncology | SPRINGER | Published : 2020

Abstract

BACKGROUND: Isolated limb infusion (ILI) is used to treat in-transit melanoma metastases confined to an extremity. However, little is known about its safety and efficacy in octogenarians and nonagenarians (ON). PATIENTS AND METHODS: ON patients (≥ 80 years) who underwent a first ILI for American Joint Committee on Cancer seventh edition stage IIIB/IIIC melanoma between 1992 and 2018 at nine international centers were included and compared with younger patients (< 80 years). A cytotoxic drug combination of melphalan and actinomycin-D was used. RESULTS: Of the 687 patients undergoing a first ILI, 160 were ON patients (median age 84 years; range 80-100 years). Compared with the younger cohort (..

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