Journal article

A multifunctional surfactant catalyst inspired by hydrolases

Mitchell D Nothling, Zeyun Xiao, Nicholas S Hill, Mitchell T Blyth, Ayana Bhaskaran, Marc-Antoine Sani, Andrea Espinosa-Gomez, Kevin Ngov, Jonathan White, Tim Buscher, Frances Separovic, Megan L O'Mara, Michelle L Coote, Luke A Connal

Science Advances | American Association for the Advancement of Science | Published : 2020


The remarkable power of enzymes to undertake catalysis frequently stems from their grouping of multiple, complementary chemical units within close proximity around the enzyme active site. Motivated by this, we report here a bioinspired surfactant catalyst that incorporates a variety of chemical functionalities common to hydrolytic enzymes. The textbook hydrolase active site, the catalytic triad, is modeled by positioning the three groups of the triad (-OH, -imidazole, and -CO2H) on a single, trifunctional surfactant molecule. To support this, we recreate the hydrogen bond donating arrangement of the oxyanion hole by imparting surfactant functionality to a guanidinium headgroup. Self-assembly..

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Awarded by U.S. Army International Technology Centre Pacific ITC-PAC

Awarded by Australian Research Council (ARC)

Awarded by ARC Centre of Excellence for Electromaterials Science

Awarded by ARC Laureate Fellowship

Funding Acknowledgements

Funding from the U.S. Army International Technology Centre Pacific ITC-PAC FA5209-14-C-0017 and the Australian Research Council (ARC)(DP200100535) is gratefully acknowledged (to L.A.C. and M.L.O.). M.D.N. and L.A.C. acknowledge the Australia Science Endowment Fund (SIEF) for a John Stoker postgraduate Scholarship, as well as an Endeavour Research Fellowship and Australian Nanotechnology Network Overseas Travel Fellowship (to M.D.N.). M.L.C. acknowledges financial support from the ARC Centre of Excellence for Electromaterials Science (CE140100012), an ARC Laureate Fellowship (FL170100041), and supercomputing time from the National Computational Infrastructure.