Regional changes in thalamic shape and volume with increasing age
Emer J Hughes, Jacqueline Bond, Patricia Svrckova, Antonis Makropoulos, Gareth Ball, David J Sharp, A David Edwards, Joeseph V Hajnal, Serena J Counsell
NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2012
The thalamus undergoes significant volume loss and microstructural change with increasing age. Alterations in thalamo-cortical connectivity may contribute to the decline in cognitive ability associated with aging. The aim of this study was to assess changes in thalamic shape and in the volume and diffusivity of thalamic regions parcellated by their connectivity to specific cortical regions in order to test the hypothesis age related thalamic change primarily affects thalamic nuclei connecting to the frontal cortex. Using structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), we assessed thalamic volume and diffusivity in 86 healthy volunteers, median (range) age 44 (..View full abstract
Awarded by Medical Research Council
The authors acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust and the Medical Research Council (UK).